HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chlorosulfonyl)benzoic acid → 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chlorosulfonyl)benzoic acid | HCID 82385 | — |
| Reactant | N-Methyl-4-(trifluoromethyl)aniline | HCID 15099755 | — |
| Product | 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid | HCID 66762384 | — |
Reaction Steps
4-(chlorosulfonyl)benzoic acid (0.5 g, 2.27 mmol) was treated with N-methyl-4-(trifluoromethyl)aniline (1191 mg, 6.80 mmol) using method A to give 4-(N-methyl-N-(4-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid as a white solid. Yield: 385 mg (47%). 1H-NMR: 8.11 (d, J=8.5 Hz, 2H), 7.74 (d, J=8.5 Hz, 2H), 7.66 (d, J=8.5 Hz, 2H), 7.39 (d, J=8.5 Hz, 2H), 3.21 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09416101B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-45dc6cdff2684b9aa38b5fa5db3f3e61 |
| Source note | uspto-grants-2016_08 |