Triethylamine → HCID 118161935, compound

HRID 1482873Notes

Reaction equation

Cl.[F:2][C:3]([F:25])([F:24])[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]3[O:18][N:17]=[C:16]([O:19][CH2:20][CH2:21][NH2:22])[C:15]=3[CH:23]=2)=[CH:7][CH:6]=1.CS([C:30]1[N:35]=[CH:34][CH:33]=[CH:32][N:31]=1)(=O)=O.C(N(CC)CC)C>C(O)C>[F:25][C:3]([F:2])([F:24])[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:12]=[CH:13][C:14]3[O:18][N:17]=[C:16]([O:19][CH2:20][CH2:21][NH:22][C:30]4[N:35]=[CH:34][CH:33]=[CH:32][N:31]=4)[C:15]=3[CH:23]=2)=[CH:7][CH:6]=1

Participants

Conditions

Temperature: 120 °C

Procedure

2-((5-(4-(trifluoromethoxy)phenyl)benzo[d]isoxazol-3-yl)oxy)ethanamine hydrochloride (57 mg, 0.152 mmol) and 2-(methylsulfonyl)pyrimidine (96 mg, 0.608 mmol) were dissolved in 2 mL ethanol in a microwave vial. Triethylamine (0.1 mL) was added and the mixture was heated at 120° C. for one hour in the microwave. All volatiles were removed under vacuum and the residue was purified on 12 g silica gel with 0-100% ethyl acetate in hexane to give the title compound (40 mg, 0.096 mmol). MS: 417 (MH+).

Workup

customAll volatiles were removed under vacuum
customthe residue was purified on 12 g silica gel with 0-100% ethyl acetate in hexane

Sources & evidence

ORD record: ord-8ac4a82e4d5e4de2b62a774f571f0c44
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09416115B2

Reaction notes

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