反应详情

温度

25 °C

A mixture of methyl trans-4-{1-[5-(3-{[4-(difluoromethyl)pyrimidin-2-yl]amino}-5-methylphenyl)pyrimidin-2-yl]ethenyl}cyclohexanecarboxylate (5 mg, 10.43 μmol) and palladium on carbon (5 mg, 10 wt %) in THF (10 mL) was stirred at 25° C. under a hydrogen atmosphere (45 psi) for 16 hours. The mixture was then filtered and the filtrate was concentrated under reduced pressure to afford methyl trans-4-{1-[5-(3-{[4-(difluoromethyl)pyrimidin-2-yl]amino}-5-methylphenyl)pyrimidin-2-yl]ethyl}cyclohexanecarboxylate. MS ESI calc'd for C26H30F2N5O2 [M+H]+ 482. found 482.

1. filtrationThe mixture was then filtered
2. concentrationthe filtrate was concentrated under reduced pressure