Hydrochloric Acid → HCID 118208179, compound

Participants

Reaction Conditions

Reaction Steps

Step b): To a solution of (S)-tert-butyl 2-(4-(5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamido)phenyl)morpholine-4-carboxylate (106 mg, 229 μmol, Eq: 1.00) in dioxane (298 μl) was added 4 M HCl in dioxane (858 μl, 3.43 mmol, Eq: 15). The reaction mixture was stirred at 60° C. overnight. To the mixture was added 2 ml of dioxane and stirred for 15 min at room temperature. The mixture was filtered and concentrated under high vacuum to give the expected HCl salt as a white solid (82 mg, 90%)

Provenance & Evidence