Hydrochloric Acid → HCID 118208179, compound

HRID 1482908Notes

Reaction equation

HRID 1482908 reaction equation
[CH3:1][C:2]1[C:3]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([C@@H:22]3[O:27][CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]3)=[CH:18][CH:17]=2)=[O:14])=[N:4][N:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[ClH:35]>O1CCOCC1>[ClH:35].[CH3:1][C:2]1[C:3]([C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([C@@H:22]3[O:27][CH2:26][CH2:25][NH:24][CH2:23]3)=[CH:18][CH:17]=2)=[O:14])=[N:4][N:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90048122HCID 90048122, compound

Product 1

HCID 118208179HCID 118208179, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent3×

Conditions

Temperature
60 °C

Procedure

Step b): To a solution of (S)-tert-butyl 2-(4-(5-methyl-2-phenyl-2H-1,2,3-triazole-4-carboxamido)phenyl)morpholine-4-carboxylate (106 mg, 229 μmol, Eq: 1.00) in dioxane (298 μl) was added 4 M HCl in dioxane (858 μl, 3.43 mmol, Eq: 15). The reaction mixture was stirred at 60° C. overnight. To the mixture was added 2 ml of dioxane and stirred for 15 min at room temperature. The mixture was filtered and concentrated under high vacuum to give the expected HCl salt as a white solid (82 mg, 90%)

Workup

  1. stirringstirred for 15 min at room temperature
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under high vacuum

Sources & evidence

ORD record
ord-9875d72f4cab4b799adde9728ca82c59
Source dataset
uspto-grants-2016_08
Patent number
US09416127B2

Reaction notes

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