HCID 90079356, compound → HCID 66212377, compound

HRID 1482940Notes

Reaction equation

HRID 1482940 reaction equation
C(OC([N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][N:12]([C:16](=[O:24])[C:17]3[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=3)[CH2:13]2)[CH2:9]1)=O)(C)(C)C>Cl.C(O)(C)C>[Br:23][C:20]1[CH:19]=[CH:18][C:17]([C:16]([N:12]2[CH2:11][CH:10]3[CH:14]([CH2:15][NH:8][CH2:9]3)[CH2:13]2)=[O:24])=[CH:22][CH:21]=1

Participants

3

Reactant 1

HCID 90079356HCID 90079356, compound

Product 1

HCID 66212377HCID 66212377, compoundYield 109.7%

Reagents, catalysts & solvents 1

HCID 21912024Isopropanol hydrochlorideSolvent

Procedure

1.2 5-(4-Bromo-benzoyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl ester (1.1 g; 2.78 mmol) is dissolved in 15 ml of HCl/Isopropanol (5-6N) and then stirred at RT for 2 hrs. The reaction mixture is reduced to dryness under vacuo to yield 0.90 g (97.5%) (4-bromo-phenyl)-(hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-methanone 2.

Sources & evidence

ORD record
ord-75e76331e2c94d4b9608358a822bca4e
Source dataset
uspto-grants-2016_08
Patent number
US09416133B2

Reaction notes

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