Chlorodiisopropylphosphine → HCID 118467176, compound

HRID 1483197Notes

Reaction equation

HRID 1483197 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:21]3[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=3[C:15]3[C:10]2=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH:6]=[CH:7][CH:8]=1.Cl[P:23]([CH:27]([CH3:29])[CH3:28])[CH:24]([CH3:26])[CH3:25]>C1(C)C=CC=CC=1>[CH:24]([P:23]([CH:27]([CH3:29])[CH3:28])[C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[CH:6][C:5]=1[N:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[C:16]2[C:21]1=[CH:20][CH:19]=[CH:18][CH:17]=2)([CH3:26])[CH3:25]

Participants

4

Reactant 2

HCID 538967ChlorodiisopropylphosphineHCID 71173478HCID 71173478, compound

Product 1

HCID 118467176HCID 118467176, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Title compound (1-2) (5.0 g) was obtained as a colorless powder by the same procedure as in the second step of Example 1, except that the reaction was conducted by use of the toluene solution of the crude product of N-(3-methoxyphenyl) carbazole (4-1) in an amount equivalent to 18.3 mmol, that chlorodiisopropylphosphine was used instead of Cy2PCl, and further that the product was isolated and purified by crystallization from toluene/methanol. Two Steps Overall Isolated Yield: 70.2%.

Workup

  1. customfurther that the product was isolated
  2. custompurified by crystallization from toluene/methanol
  3. customTwo Steps Overall Isolated Yield: 70.2%

Sources & evidence

ORD record
ord-2c10b587d36f48cf800a6ffa6bf28c01
Source dataset
uspto-grants-2016_08
Patent number
US09416148B2

Reaction notes

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