反应详情

To a stirred mixture of compound F5 (157 mg, 0.400 mmol) in methylene chloride (50 mL) at room temperature was added hydrochloride (2 M in diethyl ether, 0.300 mL, 0.600 mmol). After addition, the mixture was concentrated under reduced pressure. The resulting solid was triturated with methylene chloride and filtered to afford compound F6 as yellow solid: 1H NMR (500 MHz, DMSO-d6) δ 10.94 (s, 1H), 10.84 (bs, 1H), 10.22 (s, 1H), 7.75-6.90 (m, 5H), 4.49 (d, J=14.5 Hz, 1H), 4.22-4.16 (m, 1H), 3.65-3.62 (m, 1H), 3.38-3.05 (m, 5H), 2.30 (s, 3H), 1.32 (t, J=7.2 Hz, 3H). MS (M+H) 393.

1. additionAfter addition
2. concentrationthe mixture was concentrated under reduced pressure
3. customThe resulting solid was triturated with methylene chloride
4. filtrationfiltered