Benzoyl chloride, 3-nitro- → HCID 22060232, compound

HRID 1483292Notes

Reaction equation

HRID 1483292 reaction equation
[N+](C1C=C(C=CC=1)C(Cl)=O)([O-])=O.N1CCC(C(OCC)=O)CC1.[CH2:24]([O:26][C:27]([CH:29]1[CH2:34][CH2:33][N:32]([C:35]([C:37]2[CH:42]=[CH:41][CH:40]=[C:39]([N+:43]([O-])=O)[CH:38]=2)=[O:36])[CH2:31][CH2:30]1)=[O:28])[CH3:25]>>[CH2:24]([O:26][C:27]([CH:29]1[CH2:30][CH2:31][N:32]([C:35]([C:37]2[CH:38]=[C:39]([CH:40]=[CH:41][CH:42]=2)[NH2:43])=[O:36])[CH2:33][CH2:34]1)=[O:28])[CH3:25]

Participants

4

Reactant 3

HCID 8495Benzoyl chloride, 3-nitro-HCID 70770Ethyl 4-piperidinecarboxylateHCID 779752Ethyl 1-(3-nitrobenzoyl)piperidine-4-carboxylate

Product 1

HCID 22060232HCID 22060232, compound

Procedure

In like manner to the preparation of 3-(N-morpholinocarbonyl)aniline, 3-nitrobenzoylchloride and ethyl isonipecotate were reacted to prepare 1-[4-(ethoxycarbonyl)piperidinocarbonyl]-3-nitrobenzene which underwent hydrogenation to provide 3-[4-(ethoxycarbonyl)piperidinocarbonyl]aniline.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3654b09b9425417ca9fe5ae40906d1ef
Source dataset
uspto-grants-2016_08
Patent number
US09416112B2

Reaction notes

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