Hydrochloric Acid → HCID 66759544, compound

HRID 1483512Notes

Reaction equation

HRID 1483512 reaction equation
[CH2:1]1[CH2:10][O:9][C:8]2[CH:7]=[CH:6][C:5]([NH:11][C:12]3[C:17]([F:18])=[CH:16][N:15]=[C:14]([NH:19][C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH2:27][CH2:28][NH:29][CH3:30])[CH:21]=4)[N:13]=3)=[CH:4][C:3]=2[O:2]1.[ClH:31]>>[ClH:31].[CH2:1]1[CH2:10][O:9][C:8]2[CH:7]=[CH:6][C:5]([NH:11][C:12]3[C:17]([F:18])=[CH:16][N:15]=[C:14]([NH:19][C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([O:26][CH2:27][CH2:28][NH:29][CH3:30])[CH:21]=4)[N:13]=3)=[CH:4][C:3]=2[O:2]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66759295HCID 66759295, compound

Product 1

HCID 66759544HCID 66759544, compound

Procedure

In like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[2-(N-piperazino)carbonylbenzofuran-5-yl]-2,4-pyrimidinediamine Hydrogen Chloride Salt, the reaction of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[3-[2-(N-methylamino)ethyloxy]phenyl]-2,4-pyrimidinediamine with hydrogen chloride (4M, dioxane) gave N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[3-[2-(N-methylamino)ethyloxy]phenyl]-2,4-pyrimidinediamine Hydrogen Chloride Salt. LCMS: ret. time: 15.88 min.; purity: 92%; MS (m/e): 412 (MH+).

Workup

  1. customIn like manner to the preparation of N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-[2-(N-piperazino)carbonylbenzofuran-5-yl]-2,4-pyrimidinediamine Hydrogen Chloride Salt

Sources & evidence

ORD record
ord-07218d1fe6314938bbc09dd6a182aea3
Source dataset
uspto-grants-2016_08
Patent number
US09416112B2

Reaction notes

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