Trifluoroacetic acid → HCID 66598154, compound

HRID 1483797Notes

Reaction equation

HRID 1483797 reaction equation
O=C1CC(CN[C:10]2[CH:11]=[CH:12][C:13]3[N:14]([C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][C:26]([F:29])([F:28])[F:27])[CH:20]=4)=[CH:17][N:18]=3)[N:15]=2)CCN1C(OC(C)(C)C)=O.[C:37](O)([C:39](F)(F)F)=[O:38]>C(Cl)Cl>[NH2:14][CH2:13][CH:12]1[CH2:11][CH2:10][N:15]([C:10]2[CH:11]=[CH:12][C:13]3[N:14]([C:16]([C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][C:26]([F:27])([F:28])[F:29])[CH:20]=4)=[CH:17][N:18]=3)[N:15]=2)[C:37](=[O:38])[CH2:39]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66598070HCID 66598070, compound

Product 1

HCID 66598154HCID 66598154, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of compound tert-butyl 2-oxo-4-(((3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)methyl)piperidine-1-carboxylate (114 mg, 0.23 mmol) in CH2Cl2 (10 mL) was added TFA (2 mL). The mixture was stirred at room temperature for 30 min and condensed. The residue was purified by prep-HPLC to give 4-(aminomethyl)-1-(3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)piperidin-2-one as white solid.

Workup

  1. customcondensed
  2. customThe residue was purified by prep-HPLC

Sources & evidence

ORD record
ord-d7a25d556b1f4102a7faa0c5826776a6
Source dataset
uspto-grants-2016_08
Patent number
US09416132B2

Reaction notes

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