Hydrogen chloride-ethyl acetate → HCID 178511567, compound

HRID 1483805Notes

Reaction equation

HRID 1483805 reaction equation
C(OC([NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C.CC(=O)OCC.Cl>CCOC(C)=O>[NH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178453972HCID 178453972, compound

Product 1

HCID 178511567HCID 178511567, compoundYield 124.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of trans-4-((tert-butoxycarbonyl)amino)cyclohexanecarboxylic acid (823 g, 3.38 mol) in EtOAc (4000 mL) was added EA/HCl (2500 mL). The mixture was stirred at 0° C. overnight. The reaction mixture was filtered and dried in vacuo to give a product of hydrochloride salt of trans-4-aminocyclohexanecarboxylic acid as white solid (604 g, 99.42% yield).

Workup

  1. filtrationThe reaction mixture was filtered
  2. customdried in vacuo

Sources & evidence

ORD record
ord-5d7597ff05094e4c9d3a9dd9ba820559
Source dataset
uspto-grants-2016_08
Patent number
US09416132B2

Reaction notes

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