反应详情

温度

50 °C

A mixture of 2-(trans-4-(dibenzylamino)cyclohexyl)propan-2-ol (120 g×8, 356 mmol) and Pd(OH)2 (15 g×8) in methanol (1000 mL) and MeOH/NH3 (100 mL) was stirred under H2 (50 psi) at 50° C. for 72 hrs, then the catalyst was removed and the filtrate was concentrated in vacuo and The crude product was chromatographed on silica gel (DCM/MeOH 20:1-DCM/MeOH/NH3 5:4:1) to give the 2-(trans-4-aminocyclohexyl)propan-2-ol as a pale yellow solid (210 g, 47.5% yield).

1. customthe catalyst was removed
2. concentrationthe filtrate was concentrated in vacuo
3. customThe crude product was chromatographed on silica gel (DCM/MeOH 20:1-DCM/MeOH/NH3 5:4:1)