1-Benzyl-4-piperidone → HCID 12718203, compound

HRID 1483909Notes

Reaction equation

HRID 1483909 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5](I)[CH:6]=[CH:7][CH:8]=1.[CH2:12]([N:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH2:21][CH2:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[CH2:24][CH2:23][C:22]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:11])([F:10])[F:1])[CH:4]=2)([OH:25])[CH2:21][CH2:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 192201-Benzyl-4-piperidoneHCID 67868Benzene, 1-iodo-3-(trifluoromethyl)-

Product 1

HCID 12718203HCID 12718203, compoundYield 47.3%

Procedure

Beginning with 3-trifluoromethyl-iodobenzene (3 g) and 1-benzyl-4-piperidone (2.1 g), 1.75 g of the title compound was recovered by the procedure described in preparation 1. MS m/z (rel. intensity, 70 eV) 335 (M+, 29), 244 (22), 146 (19), 91 (bp), 56 (19).

Sources & evidence

ORD record
ord-6861d7fd0eb841c0af4e0bf97ee4bb1e
Source dataset
uspto-grants-2016_08
Patent number
USRE046117E1

Reaction notes

Loading…