Hydrochloric Acid → 4-(3-(Trifluoromethyl)Phenyl)Piperidine

HRID 1483913Notes

Reaction equation

HRID 1483913 reaction equation
C([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl>>[F:23][C:20]([F:21])([F:22])[C:16]1[CH:15]=[C:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 13127300HCID 13127300, compound

Product 1

HCID 117363404-(3-(Trifluoromethyl)Phenyl)PiperidineYield 96.1%

Procedure

Beginning with 1-Benzyl-4-(3-trifluoromethyl-phenyl)-1,2,3,6-tetrahydro-pyridine (1.44 g), 1 g of the title compound as HCl salt was recovered by the procedure described in preparation 9. m.p. 202° C. (HCl); MS m/z (rel. intensity, 70 eV) 229 (M+, 44), 228 (33), 83 (12), 57 (54), 56 (bp).

Sources & evidence

ORD record
ord-f0268d600b224104b953b50c4b923c8c
Source dataset
uspto-grants-2016_08
Patent number
USRE046117E1

Reaction notes

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