Piperazine → 1-[3-[(Trifluoromethyl)sulfonyl]phenyl]piperazine

HRID 1483916Notes

Reaction equation

HRID 1483916 reaction equation
Br[C:2]1[CH:3]=[C:4]([S:8]([C:11]([F:14])([F:13])[F:12])(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1>>[F:12][C:11]([F:14])([F:13])[S:8]([C:4]1[CH:3]=[C:2]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH:7]=[CH:6][CH:5]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 223978261-Bromo-3-((trifluoromethyl)sulfonyl)benzene

Product 1

HCID 223978251-[3-[(Trifluoromethyl)sulfonyl]phenyl]piperazine

Procedure

Beginning with 3-bromo-trifluoromethanesulfonyl-benzene and piperazine, the titled cmp was recovered by the procedure described in Preparation 17. MS m/z (rel. intensity, 70 eV) 294 (M+, 22), 252 (bp), 119 (32), 104 (10), 56 (15). (45).

Workup

  1. customthe titled cmp was recovered by the procedure
  2. customdescribed in Preparation 17

Sources & evidence

ORD record
ord-7e50c0cf03ae4e459bb8d81655c0643f
Source dataset
uspto-grants-2016_08
Patent number
USRE046117E1

Reaction notes

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