Sucrose → Phentermine

HRID 1484012Notes

Reaction equation

HRID 1484012 reaction equation
C(O)[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O.[CH3:24][C:25]([NH2:34])([CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH3:26].Cl>>[CH3:26][C:25]([NH2:34])([CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH3:24]

Participants

3

Reactant 2

HCID 5988SucroseHCID 70969Phentermine Hydrochloride

Product 1

HCID 4771Phentermine

Procedure

Preparation method: 400 g of blank sucrose pellet cores (0.71-0.85 mm) was placed in a centrifugation pelletizer; 74.7 g of phentermine hydrochloride (corresponding to 60 g of phentermine) that had passed through 80-mesh sieve was weighed and added in a feeder of the pelletizer, the rotation speed of main engine was set at 250-330 rpm, air blast flow was 400 L/min, air injection flow was 15-20 L/min, air injection pressure was 0.5-0.6 MPa, 45 ml of 3% (w/v) aqueous solution of hydropropyl methyl cellulose (HPMC) was used as binding agent, solution spray rate was 3-6 ml/min, and rotation speed of powder feeder was 10-20 r/min, so that drug powder was uniformly laminated on mother cores, the material was taken out after the end of powder feeding, and dried at 60° C. for 2 h, to obtain rapid-release pellet of phentermine.

Workup

  1. customPreparation method
  2. additionadded in a feeder of the pelletizer
  3. customdried at 60° C. for 2 h

Sources & evidence

ORD record
ord-b3a930e98b4a41d199750c769fc2ebfb
Source dataset
uspto-grants-2016_08
Patent number
US09421188B2

Reaction notes

Loading…