Phentermine → beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate, mixt. with alpha,alpha-dimethylbenzeneethanamine

HRID 1484014Notes

Reaction equation

[CH3:1][C:2]1([CH3:22])[O:10][C@@H:9]2[C@@H:4]([CH2:5][O:6][C@@:7]3([CH2:16][O:17][S:18]([NH2:21])(=[O:20])=[O:19])[O:13][C:12]([CH3:15])([CH3:14])[O:11][C@H:8]32)[O:3]1.[CH3:23][C:24]([NH2:33])([CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH3:25].CC(N)(CC1C=CC=CC=1)C.Cl>>[CH3:25][C:24]([NH2:33])([CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)[CH3:23].[CH3:1][C:2]1([CH3:22])[O:10][C@@H:9]2[C@@H:4]([CH2:5][O:6][C@@:7]3([CH2:16][O:17][S:18]([NH2:21])(=[O:20])=[O:19])[O:13][C:12]([CH3:14])([CH3:15])[O:11][C@H:8]32)[O:3]1

Participants

Reactant 3

HCID 4771Phentermine

HCID 70969Phentermine Hydrochloride

HCID 5284627Topiramate2×

Product 1

HCID 9848354beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate, mixt. with alpha,alpha-dimethylbenzeneethanamine

Procedure

The sustained-release pellet of topiramate as prepared in Example 12 and the phentermine pellet as prepared according to Formulation 19 in Example 11 were homogeneously mixed in certain weight ratio via content calculation, and then filled into capsules so that each capsule contained 23 mg of topiramate and 4.67 mg of phentermine hydrochloride (corresponding to 3.75 mg of phentermine).

Workup

additionwere homogeneously mixed in certain weight ratio via content calculation
additionfilled into capsules so that each capsule

Sources & evidence

ORD record: ord-e62969ddd9174b64bf756ffa0df520e6
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09421188B2

Reaction notes

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