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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1484014Generated: October 30, 2026

Phentermine → beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate, mixt. with alpha,alpha-dimethylbenzeneethanamine

https://huagongshe.com/reaction/1484014

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhentermineHCID 4771—
ReactantPhentermine HydrochlorideHCID 70969—
ReactantTopiramateHCID 5284627—
Productbeta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate, mixt. with alpha,alpha-dimethylbenzeneethanamineHCID 9848354—

Reaction Steps

The sustained-release pellet of topiramate as prepared in Example 12 and the phentermine pellet as prepared according to Formulation 19 in Example 11 were homogeneously mixed in certain weight ratio via content calculation, and then filled into capsules so that each capsule contained 23 mg of topiramate and 4.67 mg of phentermine hydrochloride (corresponding to 3.75 mg of phentermine).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09421188B2
Source datasetuspto-grants-2016_08
ORD IDord-e62969ddd9174b64bf756ffa0df520e6
Source noteuspto-grants-2016_08