反应详情

2.0 g dimethyl 3,3′-(1,8-naphthyridine-2,7-diyl)dibenzoate was dissolved in 60 mL of mixed solvent of THF and MeOH (v/v=1:1), 20 mL of 2N NaOH aqueous solution was added. The mixture was stirred at room temperature overnight. After the organic phase was removed, the aqueous phase was acidified with dilute hydrochloric acid to give white precipitate, which was filtered and washed with water several times. Yield: 1.73 g, 93%. 1H NMR (300 MHz, DMSO-d6): δ 7.74 (t, 2H), 8.12 (d, 2H), 8.36 (d, 2H), 8.60 (d, 2H), 8.64 (d, 2H), 8.97 (s, 2H).

1. additionwas added
2. customAfter the organic phase was removed
3. customto give white precipitate, which
4. filtrationwas filtered
5. washwashed with water several times