Diethyl Ether → HCID 14183813, compound

To a solution of N-(3-hydroxypropyl)trifluoroacetamide (1.6 g, 9.3 mmol) in anhydroud DCM (10 mL) cooled to 0° C. was added a solution of Dess-Martin periodinane (30 mL of 15 wt % in DCM; 14 mmol). Stirring was continued at 0° C. for 10 min, then the mixture was allowed to warm to room temperature and stirring was continued for 2 h. The mixture was poured onto a biphasic mixture of saturated aqueous NaHCO3 (60 mL) and Et2O (60 mL) and stirred vigorously for 20 min. The forming precipitate was eliminated by filtration and the layers separated. The aqueous layer was extracted with Et2O. The combined organic layers were washed with brine, dried (MgSO4), filtrated, and evaporated. The product was purified by column chromatography (Hex:EtOAc 3:2) to provide N-(3-oxopropyl)trifluoroacetamide as a viscous liquid in a yield of 0.82 g (52%). The product decomposes at room temperature and was used within 24 h of preparation. 1H-NMR (500 MHz, CDCl3): δ=2.84 ppm (t, J=6.0 Hz, 2H), 3.64 ppm (dt, J=6.0, 6.0 Hz, 2H), 6.98 ppm (bs, 1H), 9.81 ppm (s, 1H); 13C-NMR (500 MHz, CDCl3): δ=33.36, 42.58, 115.74 ppm (q, J=1144 Hz), 157.42 ppm (q, J=146.5 Hz), 200.85 ppm.

1. stirringstirring
2. waitwas continued for 2 h
3. stirringstirred vigorously for 20 min
4. filtrationThe forming precipitate was eliminated by filtration
5. customthe layers separated
6. extractionThe aqueous layer was extracted with Et2O
7. washThe combined organic layers were washed with brine
8. dry with materialdried (MgSO4)
9. filtrationfiltrated
10. customevaporated
11. customThe product was purified by column chromatography (Hex:EtOAc 3:2)

ORD record

ord-b52a696e56f94e5a8cc7a4c4a79310cb

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09422232B2