反应详情

温度

50 °C

To a solution of 1-tert-butyl-7-(methoxymethoxy)-1,3-dihydroisobenzofuran (Intermediate 4, 260 mg, 1.10 mmol) in Methanol (10 mL) a 6N aqueous solution of hydrogen chloride (0.18 ml, 1.10 mmol) was added and the reaction mixture was stirred for 10 hours at 50° C. Volatiles were removed under reduced pressure and the residue was partitioned between water (10 ml) and ethyl acetate (20 ml). The organic layer was dried (Na2SO4), filtered and evaporated affording the title compound (220 mg) as white solid.

1. customVolatiles were removed under reduced pressure
2. customthe residue was partitioned between water (10 ml) and ethyl acetate (20 ml)
3. dry with materialThe organic layer was dried (Na2SO4)
4. filtrationfiltered
5. customevaporated