Sodium Hydroxide → HCID 178428552, compound

HRID 1484573Notes

Reaction equation

HRID 1484573 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([C:22]([F:25])([F:24])[F:23])=[C:5]([C:20]#[N:21])[C@@H:6]([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][N:14]=[C:13]3[CH3:19])[C:7]=1[C:8]#[N:9].[OH-].[Na+:27]>C1COCC1>[C:8]([C:7]1[C@H:6]([C:10]2[CH:11]=[C:12]3[C:16](=[CH:17][CH:18]=2)[NH:15][N:14]=[C:13]3[CH3:19])[C:5]([C:20]#[N:21])=[C:4]([C:22]([F:23])([F:25])[F:24])[N-:3][C:2]=1[CH3:1])#[N:9].[Na+:27]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178428546HCID 178428546, compound

Product 1

HCID 178428552HCID 178428552, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a suspension of 200 mg (0.583 mmol) (4S)-2-methyl-4-(3-methyl-1H-indazol-5-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarbonitrile (Example 6) in THF (6 ml) under argon atmosphere was added 612 μl (0.612 mmol) 1 N aqueous sodium hydroxide solution, and the mixture was stirred under a weak argon stream for 3 days at room temperature. The product was crystallized by stirring the resulting solid in water under a slight argon stream for another 3 days to dryness, yielding 212 mg (100% of th.) of the title compound as a solid.

Workup

  1. customThe product was crystallized
  2. stirringby stirring the resulting solid in water under a slight argon stream for another 3 days to dryness

Sources & evidence

ORD record
ord-2119c803f9424a5c859869898c8367e8
Source dataset
uspto-grants-2016_08
Patent number
US09422263B2

Reaction notes

Loading…