反应详情

To a suspension of 200 mg (0.583 mmol) (4S)-2-methyl-4-(3-methyl-1H-indazol-5-yl)-6-(trifluoromethyl)-1,4-dihydropyridine-3,5-dicarbonitrile (Example 6) in THF (6 ml) under argon atmosphere was added 612 μl (0.612 mmol) 1 N aqueous sodium hydroxide solution, and the mixture was stirred under a weak argon stream for 3 days at room temperature. The product was crystallized by stirring the resulting solid in water under a slight argon stream for another 3 days to dryness, yielding 212 mg (100% of th.) of the title compound as a solid.

1. customThe product was crystallized
2. stirringby stirring the resulting solid in water under a slight argon stream for another 3 days to dryness