Phosphorus oxychloride → HCID 118232987, compound

HRID 1484584Notes

Reaction equation

HRID 1484584 reaction equation
[CH3:1][CH:2]1[CH2:6][N:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[NH:4][C:3]1=O.P(Cl)(Cl)([Cl:16])=O>C(#N)C>[Cl:16][C:3]1[CH:2]([CH3:1])[CH2:6][N:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)[N:4]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 118232985HCID 118232985, compound

Product 1

HCID 118232987HCID 118232987, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
75 °C

Procedure

In another embodiment, 4-methyl-1-(pyridin-3-yl)pyrazolidin-3-one (1) in acetonitrile is chlorinated with phosphoryl chloride and the mixture is heated to about 75° C. The 3-(3-chloro-4-methyl-4,5-dihydro-1H-pyrazol-1-yl)pyridine (2) can be isolated and purified by standard techniques.

Sources & evidence

ORD record
ord-bcda2431f8b541c8ae56f4e7168421e0
Source dataset
uspto-grants-2016_08
Patent number
US09422265B2

Reaction notes

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