HCID 86692718, compound → HCID 86692719, compound

HRID 1484603Notes

Reaction equation

HRID 1484603 reaction equation
[S:1]([C:5]1[CH:25]=[CH:24][C:8]([O:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16]C(=O)OC(C)(C)C)=[CH:7][CH:6]=1)(=[O:4])(=[O:3])[NH2:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][O:9][C:8]1[CH:7]=[CH:6][C:5]([S:1]([NH2:2])(=[O:3])=[O:4])=[CH:25][CH:24]=1

Participants

4

Reactant 1

HCID 86692718HCID 86692718, compound

Product 1

HCID 86692719HCID 86692719, compoundYield 193.3%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of tert-butyl (6-(4-sulfamoylphenoxy)hexyl)carbamate (1.178 g, 3.16 mmol) in TFA (5.0 mL) and DCM (5.0 mL) was stirred at rt for overnight. After the solvent was evaporated under a steam of N2, the reaction mixture was dissolved in water (5.0 mL) and acetonitrile (5.0 mL) and lyophilized to afford 4-((6-aminohexyl)oxy)benzenesulfonamide (1.664 g) containing TFA. MS (ESI), 273.1 (M+H)+.

Workup

  1. customAfter the solvent was evaporated under a steam of N2
  2. dissolutionthe reaction mixture was dissolved in water (5.0 mL)

Sources & evidence

ORD record
ord-a9a9b8e351b14c17babe3c739887aec4
Source dataset
uspto-grants-2016_08
Patent number
US09422251B2

Reaction notes

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