Hydrochloric Acid → Hydrochloric Acid

HRID 1484804Notes

Reaction equation

HRID 1484804 reaction equation
[OH:1][CH2:2][C:3]1[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][C:4]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[ClH:22]>O1CCOCC1>[C:16]1([C:4]2[CH2:5][NH:6][CH2:7][CH2:8][C:3]=2[CH2:2][OH:1])[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1.[ClH:22]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90418721HCID 90418721, compound

Product 2

HCID 313Hydrochloric AcidHCID 90415993HCID 90415993, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solid of tert-butyl 4-(hydroxymethyl)-3-phenyl-5,6-dihydropyridine-1(2H)-carboxylate (300 mg, 1.04 mmol) in round bottom flask was added 4N HCl in dioxane (6 mL) at room temperature, after stirring for 1 h, the mixture was concentrated and dried under high vacuum to give (5-phenyl-1,2,3,6-tetrahydropyridin-4-yl)methanol as HCl salt.

Workup

  1. concentrationthe mixture was concentrated
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-8beb79da4b5e4134b9e27b7ec8dc1067
Source dataset
uspto-grants-2016_08
Patent number
US09422279B2

Reaction notes

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