Hydrochloric Acid → Hydrochloric Acid

HRID 1484819Notes

Reaction equation

HRID 1484819 reaction equation
[OH:1][CH2:2][C:3]1[CH2:4][N:5](C(OC(C)(C)C)=O)[CH2:6][CH2:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[ClH:22]>O1CCOCC1>[C:9]1([C:8]2[CH2:7][CH2:6][NH:5][CH2:4][C:3]=2[CH2:2][OH:1])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1.[ClH:22]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90416373HCID 90416373, compound

Product 2

HCID 313Hydrochloric AcidHCID 90418088HCID 90418088, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(hydroxymethyl)-4-phenyl-5,6-dihydropyridine-1(2H)-carboxylate (510 mg, 1.76 mmol) was added 4N HCl in Dioxane (3 ml), after stirring at room temperature for 1 h, it was concentrated to give (4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)methanol as HCl salt.

Workup

  1. concentrationit was concentrated

Sources & evidence

ORD record
ord-ce51e956026d453f8075934d6d0f3f92
Source dataset
uspto-grants-2016_08
Patent number
US09422279B2

Reaction notes

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