2-(4-(4-(Benzyloxy)pyrimidin-2-yl)phenyl)acetonitrile → HCID 178510754, compound

HRID 1484837Notes

Reaction equation

HRID 1484837 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]#[N:23])=[CH:17][CH:16]=2)[N:10]=1)C1C=CC=CC=1>FC(F)(F)C(O)=O>[OH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][C:22]#[N:23])=[CH:17][CH:16]=2)[N:10]=1

Participants

3

Reactant 1

HCID 581691442-(4-(4-(Benzyloxy)pyrimidin-2-yl)phenyl)acetonitrile

Product 1

HCID 178510754HCID 178510754, compoundYield 121.3%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 2-(4-(4-(benzyloxy)pyrimidin-2-yl)phenyl)acetonitrile (1.2 g) in 2,2,2-trifluoroacetic acid (15 ml) was stirred at room temperature for 2 h. Then, the solvent was removed under reduce pressure. The product was washed by ether to afford 2-(4-(4-hydroxypyrimidin-2-yl)phenyl)acetonitrile (1.02 g, 85%) as white solid. The title compound was determination by LC-MS (LC-MS (m/z)=212.1 [M+H]+)

Workup

  1. customThen, the solvent was removed
  2. washThe product was washed by ether

Sources & evidence

ORD record
ord-fe5325ae8f034decaba79288dde1dd8a
Source dataset
uspto-grants-2016_08
Patent number
US09422271B2

Reaction notes

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