N-Iodosuccinimide → HCID 178433506, compound

HRID 1484956Notes

Reaction equation

HRID 1484956 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([OH:8])[N:5]=[C:4]([OH:9])[CH:3]=1.C1C(=O)N([I:17])C(=O)C1>CC(O)=O>[I:17][C:3]1[C:4]([OH:9])=[N:5][C:6]([OH:8])=[N:7][C:2]=1[CH3:1]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 178429421HCID 178429421, compound

Product 1

HCID 178433506HCID 178433506, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The mixture of all materials (6-methylpyrimidine-2,4-diol, 20.00 g, 0.159 mol, 1.0 eq; NIS, 39.25 g, 0.174 mol, 1.1 eq; AcOH, 150 mL) was stirred well for about 7 h. It affords white solid product 5-iodo-6-methylpyrimidine-2,4-diol (37.93 g, 95%), isolated by filtration, washed with ethyl acetate. LC-MS (m/z)=252.9 [M+H]+.

Sources & evidence

ORD record
ord-6511601b66cc409eb74c219180c473c4
Source dataset
uspto-grants-2016_08
Patent number
US09422271B2

Reaction notes

Loading…