N-Iodosuccinimide → HCID 178433506, compound

Participants

Reaction Steps

The mixture of all materials (6-methylpyrimidine-2,4-diol, 20.00 g, 0.159 mol, 1.0 eq; NIS, 39.25 g, 0.174 mol, 1.1 eq; AcOH, 150 mL) was stirred well for about 7 h. It affords white solid product 5-iodo-6-methylpyrimidine-2,4-diol (37.93 g, 95%), isolated by filtration, washed with ethyl acetate. LC-MS (m/z)=252.9 [M+H]+.

Provenance & Evidence