反应详情

温度

50 °C

A mixture of 5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidine-2-carboxamide (500 mg, 1.79 mmol) and Lawesson's reagent (1.45 g, 3.58 mmol, 2.0 eq) in toluene (30 ml) and THF (20 ml) was stirred at 50° C. for 17 h, and then, concentrated. The residue was recrystallized with toluene to give the crude 5-chloro-4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrimidine-2-carbothioamide (2.3 g, directly used for the next step). LC-MS (m/z)=295.0 [M+H]+.

1. concentrationconcentrated
2. customThe residue was recrystallized with toluene