反应详情

Mixture of 4-bromo-N-cyclopropylmethyl-2-trifluoromethylbenzenesulfonamide (295 mg, 0.82 mmol), 3,5-dimethoxyaniline (142 mg, 0.92 mmol), Pd(OAc)2 (26 mg, 0.11 mmol), BINAP (70 mg, 0.11 mmol) and cesium carbonate (395 mg, 1.21 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified by Combiflash (PE-THF). Yield 48%

1. customToluene was evaporated in vacuum
2. customcrude oil was purified by Combiflash (PE-THF)