HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → N-Cyclopropylmethyl-4-phenylamino-2-trifluoromethyl-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 4-bromo-N-(cyclopropylmethyl)-2-(trifluoromethyl)benzenesulfonamide | HCID 24948367 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-Cyclopropylmethyl-4-phenylamino-2-trifluoromethyl-benzenesulfonamide | HCID 24948368 | 20% |
Reaction Steps
A mixture of 4-bromo-N-cyclopropylmethyl-2-trifluoromethylbenzenesulfonamide (183 mg, 0.51 mmol), aniline (93 mg, 1.0 mmol), Pd(OAc)2 (11 mg, 0.05 mmol), BINAP (33 mg, 0.05 mmol) and cesium carbonate (246 mg, 0.75 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified by Combiflash (PE-THF). Yield 20%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422235B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-a320e677cf7e445183f34a48f3aad4d9 |
| Source note | uspto-grants-2016_08 |