反应详情

A mixture of 4-bromo-N-cyclopropylmethyl-2-trifluoromethylbenzenesulfonamide (183 mg, 0.51 mmol), aniline (93 mg, 1.0 mmol), Pd(OAc)2 (11 mg, 0.05 mmol), BINAP (33 mg, 0.05 mmol) and cesium carbonate (246 mg, 0.75 mmol) in 15 ml toluene was relaxed for 6 hours. Toluene was evaporated in vacuum and crude oil was purified by Combiflash (PE-THF). Yield 20%

1. customToluene was evaporated in vacuum
2. customcrude oil was purified by Combiflash (PE-THF)