Water → HCID 84016145, compound

HRID 1485028Notes

Reaction equation

HRID 1485028 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]([CH3:18])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5])C.[Li+].[OH-].O>C1COCC1.CO>[CH3:18][N:9]1[C:10]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([C:4]([OH:5])=[O:3])[CH:7]=[N:8]1

Participants

5

Reactant 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 867185501-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester

Product 1

HCID 84016145HCID 84016145, compound

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.55 g; 91.37 mmol) was dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 182.73 mmol) was added. After 16 hours at ambient temperature the reaction mixture was washed with EtOAc. The aqueous layer was acidified with 1 N HCl and extracted with EtOAc which was dried and evaporated afterwards.

Workup

  1. washAfter 16 hours at ambient temperature the reaction mixture was washed with EtOAc
  2. extractionextracted with EtOAc which
  3. customwas dried
  4. customevaporated afterwards

Sources & evidence

ORD record
ord-3d7606fdbb88412eade1017ed4fd0554
Source dataset
uspto-grants-2016_08
Patent number
US09422290B2

Reaction notes

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