反应详情

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.55 g; 91.37 mmol) was dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 182.73 mmol) was added. After 16 hours at ambient temperature the reaction mixture was washed with EtOAc. The aqueous layer was acidified with 1 N HCl and extracted with EtOAc which was dried and evaporated afterwards.

1. washAfter 16 hours at ambient temperature the reaction mixture was washed with EtOAc
2. extractionextracted with EtOAc which
3. customwas dried
4. customevaporated afterwards