Acetyl chloride → HCID 75201876, compound

HRID 1485036Notes

Reaction equation

HRID 1485036 reaction equation
[CH2:1]([N:8]([CH3:26])[C:9]1[CH:10]=[C:11]([NH:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[C:12]2[N:13]([C:15]([CH3:18])=[N:16][N:17]=2)[N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCN(C(C)C)C(C)C.[C:36](Cl)(=[O:38])[CH3:37]>C(Cl)Cl>[CH2:1]([N:8]([CH3:26])[C:9]1[CH:10]=[C:11]([NH:19][CH:20]2[CH2:25][CH2:24][N:23]([C:36](=[O:38])[CH3:37])[CH2:22][CH2:21]2)[C:12]2[N:13]([C:15]([CH3:18])=[N:16][N:17]=2)[N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 81531DiisopropylethylamineHCID 86718557HCID 86718557, compound

Product 1

HCID 75201876HCID 75201876, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

N6-Benzyl-3,N6-dimethyl-N8-piperidin-4-yl-[1,2,4]triazolo[4,3-b]pyridazine-6,8-diamine (0.05 g; 0.11 mmol) was placed in 1 ml DCM and treated with DIPEA (0.04 ml; 0.23 mmol) and acetyl chloride (0.04 ml; 0.57 mmol). It was stirred at ambient temperature for 4 hours. The crude reaction mixture was purified by using reversed phase chromatography under acid conditions.

Workup

  1. customThe crude reaction mixture
  2. customwas purified

Sources & evidence

ORD record
ord-ecbf8d95284246e1a2d1ad9d895f621d
Source dataset
uspto-grants-2016_08
Patent number
US09422290B2

Reaction notes

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