(3R)-3-Amino-4-hydroxybutanoic acid → HCID 131736733, compound

HRID 1485043Notes

Reaction equation

HRID 1485043 reaction equation
[NH2:1][C@H:2]([CH2:5][C:6]([OH:8])=[O:7])[CH2:3][OH:4].O1CCOC[CH2:10]1.[ClH:15]>CO>[ClH:15].[NH2:1][C@@H:2]([CH2:3][OH:4])[CH2:5][C:6]([O:8][CH3:10])=[O:7]

Participants

4

Reactant 2

HCID 1502076(3R)-3-Amino-4-hydroxybutanoic acidHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 131736733HCID 131736733, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of L-β-homoserine (1.00 g) in methanol (8.4 mL), a 4 mol/L hydrogen chloride-1,4-dioxane solution (8.4 mL) was added and thereafter the mixture was stirred at 60° C. for 3 hours. The reaction mixture was concentrated under reduced pressure to give the titled compound as a pale yellow oil (1.42 g).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f5fb4ea35bae423f8338fe1aadb4b25c
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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