4-Chloro-3-(trifluoromethyl)benzaldehyde → HCID 118113326, compound

HRID 1485053Notes

Reaction equation

HRID 1485053 reaction equation
Cl[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH:14]1(B(O)O)[CH2:16][CH2:15]1>>[CH:14]1([C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=2[C:10]([F:13])([F:12])[F:11])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 1186424-Chloro-3-(trifluoromethyl)benzaldehydeHCID 2760897Cyclopropylboronic acid

Product 1

HCID 118113326HCID 118113326, compoundYield 87.6%

Procedure

With 4-chloro-3-(trifluoromethyl)benzaldehyde (1.00 g) and cyclopropylboronic acid (1.24 g) being used as starting materials, the same technique as in Reference Example 6-3 was applied to give the titled compound as a pale yellow oil (900 mg).

Sources & evidence

ORD record
ord-9d0296c96015443a8a19f12f0b926542
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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