4-Hydroxybenzaldehyde → HCID 178501257, compound

HRID 1485099Notes

Reaction equation

HRID 1485099 reaction equation
OC1C=CC(C=O)=CC=1.C1(CCO)CC1.[C:16]1([OH:22])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.O[C@@H:24]1[CH2:29][CH2:28][C@H:27]([C:30]([O:32][CH3:33])=[O:31])[CH2:26][CH2:25]1>>[O:22]([C@H:24]1[CH2:29][CH2:28][C@H:27]([C:30]([O:32][CH3:33])=[O:31])[CH2:26][CH2:25]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

5

Reactant 4

HCID 1264-HydroxybenzaldehydeHCID 996PhenolHCID 1376422-Cyclopropylethan-1-olHCID 178501284HCID 178501284, compound

Product 1

HCID 178501257HCID 178501257, compoundYield 44.9%

Procedure

Instead of 4-hydroxybenzaldehyde and 2-cyclopropylethanol, phenol (1.43 g) and methyl cis-4-hydroxycyclohexanecarboxylate (2.00 g) were respectively used and treated by the same technique as in Reference Example 11-1 to give methyl trans-4-phenoxycyclohexanecarboxylate as a colorless oil (1.33 g).

Workup

  1. additiontreated by the same technique as in Reference Example 11-1

Sources & evidence

ORD record
ord-c23eedd4fc894509a899d44b497a8f48
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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