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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1485105Generated: November 2, 2026

P-Cresol → HCID 114059652, compound

https://huagongshe.com/reaction/1485105

Reaction equation

Participants

RoleNameHCIDCharge
ReactantP-CresolHCID 2879—
Reactant4-(Trifluoromethyl)phenolHCID 67874—
ReactantMethyl 5-chloropyrazine-2-carboxylateHCID 406081—
ProductHCID 114059652HCID 114059652—

Reaction Steps

Instead of 4-hydroxybenzotrifluoride and 6-bromo-3-pyridinecarboxyaldehyde, p-cresol (833 mg) and methyl 5-chloro-2-pyrazinecarboxylate (1.33 g) were respectively used and treated by the same technique as in Reference Example 13-1 to give methyl 5-(4-methylphenoxyl)pyrazine-2-carboxylate as a colorless solid (1.36 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09422240B2
Source datasetuspto-grants-2016_08
ORD IDord-d001a9cbd04a449b84a28155ab95777e
Source noteuspto-grants-2016_08