P-Cresol → HCID 114059652, compound

HRID 1485105Notes

Reaction equation

HRID 1485105 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](F)(F)F)=[CH:4][CH:3]=1.C1C(O)=CC=C(C)C=1.Cl[C:21]1[N:22]=[CH:23][C:24]([C:27]([O:29][CH3:30])=[O:28])=[N:25][CH:26]=1>>[CH3:8][C:5]1[CH:6]=[CH:7][C:2]([O:1][C:21]2[N:22]=[CH:23][C:24]([C:27]([O:29][CH3:30])=[O:28])=[N:25][CH:26]=2)=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 2879P-CresolHCID 678744-(Trifluoromethyl)phenolHCID 406081Methyl 5-chloropyrazine-2-carboxylate

Product 1

HCID 114059652HCID 114059652, compound

Procedure

Instead of 4-hydroxybenzotrifluoride and 6-bromo-3-pyridinecarboxyaldehyde, p-cresol (833 mg) and methyl 5-chloro-2-pyrazinecarboxylate (1.33 g) were respectively used and treated by the same technique as in Reference Example 13-1 to give methyl 5-(4-methylphenoxyl)pyrazine-2-carboxylate as a colorless solid (1.36 g).

Workup

  1. additiontreated by the same technique as in Reference Example 13-1

Sources & evidence

ORD record
ord-d001a9cbd04a449b84a28155ab95777e
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

Loading…