Trifluoroacetic acid → HCID 118113227, compound

HRID 1485125Notes

Reaction equation

HRID 1485125 reaction equation
[C:1]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:6]=[CH:5][C:4]([CH2:7][N:8]2[C:16](=[O:17])[C:15]([C:18]([NH:20][CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])=[O:19])=[C:14]([OH:29])[CH2:13][C:9]32[CH2:12][O:11][CH2:10]3)=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[C:1]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:2]=[CH:3][C:4]([CH2:7][N:8]2[C:16](=[O:17])[C:15]([C:18]([NH:20][CH2:21][C:22]([OH:24])=[O:23])=[O:19])=[C:14]([OH:29])[CH2:13][C:9]32[CH2:10][O:11][CH2:12]3)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 118113229HCID 118113229, compound

Product 1

HCID 118113227HCID 118113227, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution in chloroform (20.0 mL) of the compound (2.60 g) obtained in step (1) above, trifluoroacetic acid (8.00 mL) was added and the mixture was stirred at room temperature for 12 hours. After concentrating under reduced pressure, ethyl acetate was added to the residue. With continued stirring, n-hexane was added and the precipitate was recovered by filtration to give the titled compound as a pale brown solid (2.18 g).

Workup

  1. concentrationAfter concentrating under reduced pressure, ethyl acetate
  2. additionwas added to the residue
  3. stirringWith continued stirring
  4. additionn-hexane was added
  5. filtrationthe precipitate was recovered by filtration

Sources & evidence

ORD record
ord-37dcaff1b36c460e8572b8e41ebea1ad
Source dataset
uspto-grants-2016_08
Patent number
US09422240B2

Reaction notes

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