6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-2,4-diamine
Reaction equation
Cl[C:2]1[N:3]=[C:4]([NH2:21])[C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:12]=[N:13][C:14]4[C:19]([CH:20]=3)=[CH:18][CH:17]=[CH:16][CH:15]=4)[C:6]=2[N:7]=1.[CH2:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[N:35]=[CH:34][C:33]([NH2:36])=[CH:32][CH:31]=2)[CH2:26][CH2:25]1)[CH3:23]>>[CH2:22]([N:24]1[CH2:25][CH2:26][N:27]([C:30]2[N:35]=[CH:34][C:33]([NH:36][C:2]3[N:3]=[C:4]([NH2:21])[C:5]4[S:10][CH:9]=[C:8]([C:11]5[CH:12]=[N:13][C:14]6[C:19]([CH:20]=5)=[CH:18][CH:17]=[CH:16][CH:15]=6)[C:6]=4[N:7]=3)=[CH:32][CH:31]=2)[CH2:28][CH2:29]1)[CH3:23]Participants
3
Procedure
The target compound of Example 30 (21 mg, 68% yield) was prepared in the same manner as Step 9 of Example 1 using 2-chloro-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-4-amine (20 mg, 0.064 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (20 mg, 0.096 mmol).
Sources & evidence
- ORD record
- ord-e03271e012df4e6fb883582793e3047f
- Source dataset
- uspto-grants-2016_08
- Patent number
- US09422307B2
Reaction notes
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