HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Ethylpiperazin-1-yl)pyridin-3-amine | HCID 9161674 | — |
| Reactant | 2-Chloro-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-4-amine | HCID 86675657 | — |
| Product | N2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-2,4-diamine | HCID 53239321 | 68% |
Reaction Steps
The target compound of Example 30 (21 mg, 68% yield) was prepared in the same manner as Step 9 of Example 1 using 2-chloro-7-(quinolin-3-yl)thieno[3,2-d]pyrimidin-4-amine (20 mg, 0.064 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (20 mg, 0.096 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09422307B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-e03271e012df4e6fb883582793e3047f |
| Source note | uspto-grants-2016_08 |