2-Morpholinoethylamine → HCID 53236148, compound

HRID 1485508Notes

Reaction equation

Cl[C:2]1[N:3]=[C:4]([NH:13][C@@H:14]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH3:15])[C:5]2[S:10][CH:9]=[C:8]([CH:11]=[CH2:12])[C:6]=2[N:7]=1.[O:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH2:30])[CH2:24][CH2:23]1>>[O:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][NH:30][C:2]2[N:3]=[C:4]([NH:13][C@@H:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH3:15])[C:5]3[S:10][CH:9]=[C:8]([CH:11]=[CH2:12])[C:6]=3[N:7]=2)[CH2:24][CH2:23]1

Participants

Reactant 2

HCID 4082852-Morpholinoethylamine

HCID 87308627HCID 87308627, compound

Product 1

HCID 53236148HCID 53236148, compoundYield 65.4%

Procedure

The target compound of Example 47 (34 mg, 65% yield) was prepared in the same manner as Step 3 of Example 44 using (R)-2-chloro-N-(1-phenylethyl)-7-vinylthieno[3,2-d]pyrimidin-4-amine (40 mg, 0.127 mmol) and 2-morpholinoethanamine (82 mg, 0.63 mmol).

Sources & evidence

ORD record: ord-cc7700e2116a459ba34e7a771b38f829
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09422307B2

Reaction notes

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