Sodium hydride → 3-Bromo-8H-8,12b-diazabenzo[a]aceanthrylene

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Reaction Steps

Under a protective gas, 25 g (72 mmol) of 2-(6-bromo-1-fluorocarbazol-9-yl)phenylamine are dissolved in 200 ml of DMF, 2.8 g (72 mmol) of NaH (60% in oil) are added at room temperature, and the mixture is heated under reflux for 6 h. The mixture is allowed to come to room temperature over the course of 1 h, the solvent is then removed, and the residue is purified by chromatography. The yield is 19 g (54 mmol), corresponding to 78% of theory.

Provenance & Evidence