反应详情

Under a protective gas, 25 g (72 mmol) of 2-(6-bromo-1-fluorocarbazol-9-yl)phenylamine are dissolved in 200 ml of DMF, 2.8 g (72 mmol) of NaH (60% in oil) are added at room temperature, and the mixture is heated under reflux for 6 h. The mixture is allowed to come to room temperature over the course of 1 h, the solvent is then removed, and the residue is purified by chromatography. The yield is 19 g (54 mmol), corresponding to 78% of theory.

1. temperaturethe mixture is heated
2. temperatureunder reflux for 6 h
3. customto come to room temperature over the course of 1 h
4. customthe solvent is then removed
5. customthe residue is purified by chromatography