反应详情

3,5 difluorophenylacetonitrile (5 g) was dissolved in THF (100 mL) and a solution of BH3 in THF (200 mL of 1 M) was added dropwise. The mixture was refluxed overnight, cooled in an ice bath, and the reaction quenched with methanol (20 mL). The solvent was removed by rotary evaporation and the residue partitioned between ethyl acetate and water. The organic layer was washed with sat NaCl and the solvent again removed to give product, which was used in the next step without purification.

1. temperatureThe mixture was refluxed overnight
2. temperaturecooled in an ice bath
3. customthe reaction quenched with methanol (20 mL)
4. customThe solvent was removed by rotary evaporation
5. customthe residue partitioned between ethyl acetate and water
6. washThe organic layer was washed with sat NaCl
7. customthe solvent again removed
8. customto give product, which
9. customwas used in the next step without purification