Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester | HCID 71073615 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (2R,3R)-3-amino-4-(2-chloro-phenyl)-2-hydroxy-butyric Acid Butyl Ester | HCID 71073857 | — |
Reaction Steps
(2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester (100 mg, 0.4 mmol) was combined with 1-butanol (5 mL) and concentrated HCl (1 mL) and heated at 70° C. for 24 hours. Excess solvent was removed to yield the title compound as an HCl salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09422245B2 |
|---|
| Source dataset | uspto-grants-2016_08 |
|---|
| ORD ID | ord-a302359673964ac79719793e5cb01884 |
|---|
| Source note | uspto-grants-2016_08 |
|---|
