Hydrochloric Acid → HCID 123681762, compound

HRID 1485914Notes

Reaction equation

HRID 1485914 reaction equation
[CH3:1][C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([CH3:11])=[C:6]([OH:12])[C:5]=2[CH3:13].N1C=CN=C1.[C:19]([Si:23](Cl)([CH3:25])[CH3:24])([CH3:22])([CH3:21])[CH3:20].Cl>CC#N>[C:19]([Si:23]([CH3:25])([CH3:24])[O:12][C:6]1[C:5]([CH3:13])=[C:4]2[C:9]([CH:10]=[C:2]([CH3:1])[CH2:3]2)=[CH:8][C:7]=1[CH3:11])([CH3:22])([CH3:21])[CH3:20]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 118413261HCID 118413261, compound

Product 1

HCID 123681762HCID 123681762, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Mixture of 2,5,7-trimethyl-1H-inden-6-ol (1.8 g, 10.3 mmol), imidazole (1.76 g, 25.8 mmol), and tert-butylchlorodimethylsilane (1.87 g, 12.4 mmol) in CH3CN (35 ml) was stirred for 16 h at room temperature, poured into 2% HCl (100 ml), extracted by pentane (4×20 ml). Combined organic fraction was washed by water, dried over MgSO4, and evaporated. The yield 2.8 g (94%).

Workup

  1. extractionextracted by pentane (4×20 ml)
  2. washCombined organic fraction was washed by water
  3. dry with materialdried over MgSO4
  4. customevaporated

Sources & evidence

ORD record
ord-287e5d45a5a54a27a6b98c4c75ec9592
Source dataset
uspto-grants-2016_08
Patent number
US09422380B2

Reaction notes

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